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To obtain additional restraints for structural model determination of the p53 TAD2 -FOXO4 FH complex, we determined paramagnetic relaxation enhancements (PREs) for a set of 7 complexes containing spin-labeled (SL) samples ( 15 N-labeled FOXO4 FH + S46C-SL p53 TAD2 , 15 N-labeled FOXO4 FH + Q52C-SL p53 TAD2 , 15 N-labeled p53 TAD2 + Q112C-SL FOXO4 FH , 15 N-labeled p53 TAD2 + D140C-SL FOXO4 FH , 15 N-labeled p53 TAD2 + N145C-SL FOXO4 FH , 15 N-labeled p53 TAD2 + S159C-SL FOXO4 FH , 15 N-labeled p53 TAD2 + S162C-SL FOXO4 FH )
Interestingly, products of lipid peroxidation may further increase overall cellular oxidative stress by facilitating the generation of free radicals through the formation of adducts with proteins, which increases direct free radical-induced protein oxidation (67)
Energy and metabolism
Glutathion wird vom Krper selbst aus den Aminosuren Glutaminsure, Cystein und Glycin gebildet und ist an vielen Stoffwechselprozessen im Krper beteiligt
Price: 60 Ingredients: Glutathione Information: Acts as an antioxidant to protect cells