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Recently, researchers have successfully engineered a dual-mechanism-based nutrient partitioning nanoregulator (DMNPN) that downregulates glutaminase expression and enhances nutrient availability for T cells, thereby bolstering their antitumor immunity [201]

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This process avoids adding external molecules since interferon gamma (IFN-) and tumor necrosis factor-alpha (TNF-), two cytokines associated to the SASP, act as natural adjuvant by promoting an immunoreaction

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