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Eight-week-old female Balb/c mice were used for the construction of an AIA model, which has been demonstrated to present similar pathologic features to human rheumatoid arthritis, such as chronic inflammation and bone destructions 43,44

We here exposed melanocytes to different ECM proteins and varying substrate stiffnesses, and identified MITF, a key regulator of melanocyte differentiation and function, as an ECM- and mechanosensitive transcription factor

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