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Potency loss can also occur without visible change, so solutions stored beyond the validated shelf life must be discarded regardless of appearance

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However, currently available drugs fall short in some cases, prompting clinicians to search for therapeutic alternatives [9]

Malabsorption disorders In this disorder, it is difficult for the body to absorb useful nutrients including vitamin B12, through the gastrointestinal tract

The presence of peripheral sensory-motor symptoms or subacute combined degeneration of the spinal cord strongly suggests the presence of a B 12 deficiency instead of folate deficiency