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Nonetheless, it is reassuring that the reductions in HbA 1c and body weight from the multiple-dose trial are consistent with those results obtained in a substantially higher number of subjects in the phase II trial with oral semaglutide [10]

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In experimental studies, specific bioactives also stimulate GLP-1 secretion, for example, polyphenols in fruits and vegetables, catechins in green tea, curcumin in turmeric, capsaicin in chili peppers, omega-3 fatty acids in fish, and cinnamon and ginger [274,275]