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GLP-1 receptor agonists are peptide drugs cleared through proteolytic cleavage essentially broken down by the same enzymatic processes that digest dietary protein

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Five studies of BPC-157 reviewed by the agency "were of short duration, had small sample sizes and evaluated doses that were likely exploratory in nature," the staffers said

The Phase 2b trial (PMID: 23714218) failed to demonstrate significant weight loss compared to placebo over 12 weeks, despite adequate sample size and dosing

This forceful action can shear and damage the delicate peptide bonds, a process known as denaturation