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HOLST: Yeah, so the way I would like to put it is there are two major areas of effects of GLP-1 that we really haven't talked about, and one is the vascular system

It's just not loud enough anymore to override your body's compensatory hunger signals, especially if you've lost significant weight and your metabolism has adjusted downward

If one dose is missed and the next scheduled dose is less than 2 days away (48 hours), do not administer the dose

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Long-Term Management: The goal is not just initial weight loss, but also helping you maintain those results by resetting your bodys signals related to hunger and fullness

This could be because it stays in the body longer and continues to activate the receptors over time, which is especially important in preventing severe hypoglycemia