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GIP receptor activation may modulate the dopamine-suppressing effects of GLP-1 receptor activation, effectively buffering the sexual side effects

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The same logic that makes MOTS-C work with Retatrutide applies to semaglutide and tirzepatide, just to a lesser degree

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However, while these results are compelling, the authors emphasize that this is a single-subject observation and underscore the need for large-scale randomized clinical trials to validate semaglutide and similar GLP-1 RAs as primary AUD treatments