Naringenin up regulated the expression of MITF by increasing the expression of -catenin and the phosphorylation of Akt or GSK3, and then increased the activity of tyrosinase, so as to improve the melanin synthesis of B16-F10 cells, rather than through cAMP pathway (Huang et al., 2011)
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doi: 10.1038/s41430-020-0677-5
It creates a permanent upstream bottleneck that compounds existing enzyme-level impairments in glutathione production
Liu H, Wu L, Fu S, Hou Y, Liu P, Cui H, et al
By inhibiting HDAC, HDACi can increase the acetylation levels of proteins