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[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration

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FDA staff had recommended against including emideltide, which is used for insomnia and opioid withdrawal, on the list in part because studies on its efficacy are limited and because there are alternative therapies available to treat those conditions

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