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Matching variables included index year, sex, age, diabetes duration, health screening variables (BMI, fasting glucose level, eGFR, smoking habit, alcohol consumption, and number of health screening examinations), comorbidities, and antidiabetic drugs

10.1067/mhj.2000.103918

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Endnotes: The efficacy estimand represents efficacy had all randomized participants remained on study intervention (with possible dose interruptions and modifications) without initiating prohibited weight management treatments (and glycemic rescue therapy for glycemic endpoints only)