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Acknowledgements We are grateful for the financial support from the National Natural Science Foundation of China (32071342 and 32101065), the Science, Technology & Innovation Commission of Shenzhen Municipality (JCYJ20220818102810023), and the Singapore National Research Foundation under Its Competitive Research Program (NRF-CRP26-2021-0002)

doi: 10.1007/s12035-017-0811-0 127

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Neurochem Int 52:12841289 Lopez-Gonzalez R, Lu Y, Gendron TF et al (2016) Poly(GR) in C9ORF72-related ALS/FTD compromises mitochondrial function and increases oxidative stress and DNA damage in iPSC-derived motor neurons