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The SUSTAIN 29,30,31,32,33,34,35 and SCALE studies 10,11,12,13,14,15 have shown robust efficacy in lowering blood glucose levels in diabetic patients and inducing weight loss in obese patients over clinical trial periods ranging from 30 to 104 weeks

About half of the participants received weekly injections of semaglutide, with the rest receiving placebo injections

However, conclusive research remains scant not least as pregnancy or intention to become pregnant were exclusion criteria in initial clinical trials of such drugs

Additional uncertainty comes from the possibility of new therapies or weight-management innovations entering the market, as well as the potential for longer-term side effects that have not yet emerged in real-world populations

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GIPR blocker: MariTide also blocks glucose-dependent insulinotropic polypeptide or GIP receptors