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In particular, COX-2 over-expression may inhibit apoptosis and increase invasiveness of malignant cells

Employing exogenous melatonin applying confers chilling tolerance in tomato fruits by upregulating ZAT2/6/12 giving rise to promoting endogenous polyamines, proline, and nitric oxide accumulation by triggering arginine pathway activity

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Moreover, lutein pretreatment prevented oxidative stress caused by light in the retinal tissues, downregulated the levels of inflammatory cytokines, and significantly attenuated the apoptotic-induced thinning of the photoreceptor cell layer and decrease in electroretinogram a- and b-wave amplitudes in rats [53]