sulfur burps and tirzepatide burps?? : r/Mounjaro Replying to @krissmagss #greenscreen sulfur

It keeps injection volumes manageable across the entire dosing range

It can slow or stop loss and sometimes regrow miniaturised hair, especially with minoxidil

2) GLP-1RAPDB2022GLP-1RA60.52018-2022CAGR70.5%(~16%)(~55%) GLP-1RA GLP-1RA202251%15%;202274.4(31%)GLP-1R/GIPR20225FDA2022/2023Q14.8/5.72030GLP-1RA2350-400GLP-18GLP-1RA2%2NDA7III9II(2023.3) FDA6(Saxenda)201412GLP-1RA;Ozempic(2017,)Rybelsus(2019,)Wegovy(2021);Tirzepatide(Mounjaro)GIPR/GLP-1R20225IIGLP-1(2023.7) GLP-1(2023.7)1(2023.7)(2023.7)GLP-1R/GIPRGLP-1R/GCGRGLP-1R/GIPRGLP-1R/GCGRGLP-1R/GCGRIBI362IIIGLP-1R/GIPR/GCGRRetatrutideIIIGLP-1R/AMYRCagriSemaIII2)GLP-1RAOrforglipronDanuglipronLotiglipronOrforglipron(II)III3)GLP-1RAFcPEG/GLP-1efpeglenatideIII4)GLP-12 GLP-1 FDAGLP-1RACDMO 1 GLP-1RA 1.1 GLP-1RA 1.1.1 GLP-1 (GLP-1)L1964 60-70% T2DM 20% GLP-1()GLP-1GLP-1 1.1.2 GLP-1 GLP-1()()50mg/dLGLP-1T2DM(ISR) GLP-1 2 1.1.3 GLP-1 GLP-1 GLP-1 934021.8mg13%22% 232972(MACE) 1.1.4 GLP-1 RA GLP-1 GLP-13 (DPP-4)(DPP-4)1-2minGLP-1DPP-4GLP-1 RAGLP-1RA23N()DPP-4GLP-1()Fc()PEG()PLGA() 1.2 GLP-1RA200 1.2.1 GLP-1RA 2005GLP-1RA GLP-1Exendin-4GLP-153%2009GLP-1GLP-197%GLP-1RAGLP-1RAGLP-1RA 1)GLP-1RA 2)GLP-1RA 3)GLP-1RA GLP-1RAExendin-4(GLP-1)GLP-1GLP-1RA 1.2.2 GLP-1RA GLP-1RA 2018-2022SGLT-2iGLP-1RA33%29%CAGRDPP-4i20235GLP-15.5%(5%0.5%)39%(36%3%) GLP-1RA20020311500 2023Q13940(591)GLP-11570(235.5)39.8%2031GLP-116501000 1.2.3 GLP-1RA GLP-1 GLP-1RAPDB2018GLP-1RA6.8202260.52018-2022CAGR70.5%Frost & Sullivan2030GLP-1RA515 GLP-1(~16%)(~55%) 1)GLP-1GLP-12)GLP-13)GLP-1RA(ASCVD)GLP-1RA 2 GLP-1RA 2.1 2.1.1 (IDF)20215.3720457.841.4112.8 Frost & Sullivan2020697202590020301100202039%GLP-1(18.8%)DPP-4(17.4%)SGLT-2(10.8%)GLP-1 2.1.2 20211.4120451.752022IO(International Operations)19%(23%)(40-50%) -Frost & Sullivan202063245.1%202511612020-202512.9% 2.2 GLP-1ADAGLP-1 2(T2DM)GLP-1ASCVDCKD 202142(2020)GLP-1T2DMGLP-1RA3(+/) T2DMASCVDGLP-1RAICKDSGLT2iGLP-1RA 2023ADAGLP-1RA 202212ADA2023T2DMT2DMT2DMASCVD/HF/CKDGLP-1RAs()(GIP)/GLP-1RA(tirzepatide)GLP-1RA 2.3 GLP-1(GLP-1 RA)-(SU(TZDs)-4(DPP-4i)--2(SGLT-2i)GLP-1 RA GLP-1 1)GLP-12)GLP-1,3)4)GLP-1RA2(T2DM) 2.4 GLP-1RA (1)-GLP-1RA GLP-1GLP-153%GLP-1RA2005GLP-1RA2-4h2 HbA1c 0.5%~1.0% 1030HbA1c7%40%0.9% 30 (10 )+22.6kg (TZD) 40%-50%Excendin-438%( 85% GLP-1RANAFLD/NASHIII F2-3NASHIII202112007251)NASH(72)2)NASH(72)3)(0-240)2029 GCGRGIPRFGF21R 20236(EASL)GLP-1GCGRefinopegdutide(MK-6024)NAFLD)IIaefinopegdutideGLP-1145efinopegdutide(10mg)(1mg)24efinopegdutide72.7%(95% CI66.878.7)42.3%(95% CI36.548.1)24efinopegdutide8.5%7.1%(p=0.085)IIb2025.12.5 4.5.2 (AD): III (AD) ADAD()AD(MCI)ADAD-(A)(NFTs) GLP-1RA TauGLP-1RA1)GLP-1ADAD2)GLP-1GLP-1RAT2DM15%19%GLP-13)GLP-1 GLP-1RAAD ADGLP-1RAAb/Tau III104CDR-SB2025 5 5.1 GLP-1 5.1.1 (1982)leuprolidegoserelin(19851989)20902000-20101990-20102 5.1.2 2-99() FDA Frost & Sullivan202062820259602019-20258.8%CDMO2020202025442019-202517.7% 5.1.3 FDA6% 1940FDA6%83%11%FDA 2023H1Top108 5.1.4 1) 2) 5.1.4 BocFmoc 1)DICDCCEDCHClHOBtHOAt2)TBTUHBTUHATUPyBOP 5.1.4 + 1000kgMounjaroAPI 42.5mg/0.5mL5mg/0.5mL415mg(Mounjaro2.5mg7.5mg10mg12.5mg15mg)5mg/0.5mLDrugs.com(5mg/)~1087 1000kg5000543.5 IIISURPASS-3521000kg400 5.1.5 GLP1-RA GLP-1RACDMO 2021API20194Polypeptide2020API1865%35%GLP-1RAGMPCDMO 5.2 5.2.1 GLP-1 2023H14650%GLP-18 1)HDM1002(GLP-1R) 20235IND20236/IND20239 2)HDM1005(GLP-1R/GIPR) 2024IND 3)DR10624 (GLP-1R/GCGR/FGF21R) 20237I(MAD)IND20237IND20236IND20238 4) 20233NMPA20236NMPA 5) IIII 6) IIII 5.2.2 843000202382BCMA CAR-TPCSK910 PCSK9202383IBI362(GLP-1R/GCGR/2)IBI128(XOI)IBI311(IGF-1R)4III IBI112(IL-23p19)IBI302(VEGF/C)2023H124.6(+20.4%)23Q235%(PD-1) 5.2.3 31 2023H149.62153(PD-L1)(DPP-42) 6 SHR-1314(IL-17A)SHR0302(JAK1)SHR8058(NOV03)SHR8028(A)SHR-1209(PCSK9)HRX0701(DPP-4/2)80270GLP-1 5.2.4 5185%202230%2022115%500020222023-2025361190% (Sandoz)BLA 201812SandozSandoz23002023FDABLAGlobalNewswire2021550 GZR18(GLP-1)GZR4()GZR101() 5.2.5 20225202214.9%100% 2011GLP-1RA20226URAT1 2022III202212GLP-1RA17 5.2.6 ()CDMO 2018CDMO/CMO2022CDMO 2023Wuxi TIDES2022Wuxi TIDES20.82023H113.370%2023H1TIDES207(+46%)121(+25%)2023H132(+68%)TIDESAPICMCTIDES30%TIDESCMC CRDMO 2023H1Wuxi TIDES4(37)6(14)1(6)11GLP-1Wuxi TIDESCRDMO2022Wuxi TIDES6000L20232wL20243.2wL20224.3522023162024312023 5.2.7 5kg20221.9(+126.3%)GLP-1RA1SPN00920227GLP-1/GIPSPN0072022920002023522cGMP1.021 (Cipla)(Cadila)Orbicular(Teva)(Dr.Reddy202111FDA(Active)202312CDE 1060.20.1520210002 5.2.8 2022CDMO1.1(+10.3%)1.4(+55.2%)1.4(-42.2%) 5.2.9 CDMO CDMO CDMO(mAb)(ADC)RNA (mRNA)CDMOCROCDMOCDMO 202210(+150.5%)3.34(+113.2%)CDMO(33.4%-5.9pp)3.7(+138.7%)20224068Phase II25-CDMO-- 20224035 5.2.10 20232692415105 202216DMF5DMF5CEP14DMF20220.9(+59.4%)112% 5.2.11 CDMO CDMO/IIIIII2023H11NDA29 III66III839NDA 202342023H12023H2 5.2.12 7-ACA20223.2(+58%) 2022seplife2-CTCsieberGLP-1sieber 5.2.13 CDMO CDMO CDMOcGMP5002012GLP-1/ cGMP 16cGMP1000L5000L300kg 5 GLP-1RA 2023919 ( SACS1250520030002 2022 /CAR-TNASHPD-1BTKCLDN18.2GLP-1HIVG-CSFADCESMOASCOCSCOEGFR CGM | | | | | | | | CXOCDMO CXO | CXO 2023H12023H1 mRNAHPVDelta | A |||| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | || | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | -B| | | | | | | | | | | | | | | | | (NVO) | (MSD) | (JNJ) | (ABBV) | (AMGN) | (SNY) | (AZN) | (PFE)

Cell fate specification begins during preimplantation development with the critical segregation of inner cell mass (ICM) and trophectoderm (TE) lineages, representing the first cell fate decision in mammalian development

For a deeper look at the mechanism behind treatment, this GLP-1 side effects guide is a helpful companion read

The US Food and Drug Administration on Wednesday approved a new obesity pill called Foundayo