Cannabis While no pre-clinical or mechanistic study has considered GLP-1RAs for cannabis misuse so far, a large epidemiological investigation has recently noted an association between semaglutide use and fewer cannabis-use disorders in both patients with T2DM ( N = 596,045) and patients with obesity ( N = 85,223) over a 1-year follow-up 114
Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk
Side-effect management is highly individual many patients do better with slower titration than the label schedule
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R., Lingvay, I., Ldemann, J., Andreassen, C., Navarria, A., & Viljoen, A
For weight management, be aware that in the UK, GLP-1 medications like Wegovy (semaglutide) and Saxenda (liraglutide) are typically only available through specialist weight management services (tier 3 or 4), with specific BMI thresholds and time-limited treatment courses as per NICE guidance