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Jalali S, et al

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Metabolomics and network pharmacology can elucidate drug mechanisms and identify disease-specific molecular targets (Luo et al., 2024

ICER attributed such denials to cost concerns: supporting these new therapies (even at net prices) creates unprecedented budget impact, and some payers have explicitly chosen not to cover them for weight-loss ( [27] ) ( [36] )

The choice usually comes down to a handful of priorities