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Two mechanisms pushing stool through the colon faster means more diarrhea at equivalent weight loss

Semaglutide frequently has a side effect of constipation, with a 24.2% incidence of this symptom in a secondary analysis of the Semaglutide Treatment Effect in People with obesity (STEP) 1-3 trials [6]

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This approach has advantages: Patients whose appendicitis is treated with antibiotics instead of an appendectomy require less pain medication and have fewer complications

Metformin & longevity Healthspan : Strong evidence shows metformin extends years of healthy life by delaying age-related diseases: Reduces cardiovascular disease risk by improving blood vessel health

They do not have to do with weight