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S2CID 25303091

Although their effects are not immediate, when taken in small doses, they often become apparent after many years or generations of exposure, and remain poorly understood [425]

No pharmaceutical company has found a way to deliver it effectively as an oral tablet

Additional Phase 3 trials are still underway, including TRIUMPH-2 (evaluating retatrutide in adults with obesity and type 2 diabetes) and TRIUMPH-3 (evaluating cardiovascular outcomes), with results expected later in 2026

Maturation skews macrophage polarization from M1 to M2 (interleukin-4 [IL-4], interleukin-10 [IL-10], IL-12, Arginase 1 [Arg-1]

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