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Biomaterials 26 , 57045716 (2005)
It was discovered in 2012,[3] by a team of researchers at Novo Nordisk as a longer-acting alternative to liraglutide.[4] Clinical trials were started in 2015, and phase 3 was completed in 2016.[5] Researchers at the University of Leeds and Novo Nordisk reported in 2017 that it can also be used for the treatment of obesity.[6] It reduces hunger, food craving and body fat.[7] FDA approval was applied in December 2016, and in October 2017 FDA Advisory Committee voted 16-0 in favour.[8] On December 5, 2017, semaglutide was approved by the US FDA
Some patients may benefit from slower dose escalation or temporary dose reduction of their GLP-1 medication if constipation becomes problematic, though this should only occur under medical supervision
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The impact of GLP-1 receptor agonist shortages on glycaemic control: findings from an Australian specialist diabetes clinic
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