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For researchers whose side effects are dose-dependent and peak-related, this can make a dramatic difference in tolerability

Tapering versus cold turkey The guide on how to wean off tirzepatide strongly recommends a gradual taper rather than abrupt discontinuation

If facial changes are a concern, your provider can discuss cosmetic options

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no human cases to date Contraindications Personal/family history of MTC or MEN 2 Hypersensitivity to tirzepatide Pregnancy (insufficient data) Discontinuation Rates 4-7% discontinued due to adverse events (primarily GI), lower than semaglutide (7-11%)

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