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We extended our investigation of the cardioprotective effects of linagliptin using a dietary murine model of over-nutrition in which 4 week old female mice were fed a high fat-high fructose diet for 4 months (WD-western diet) [35]

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Paradoxine drives thermogenesis through TRPV1 receptor activation and brown adipose tissue (BAT) stimulation a separate heat-generating mechanism that operates through adrenergic and uncoupling protein pathways independent of carnitine

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