Significantly elevated homocysteine has been observed in people suffering with cardiovascular disease, stroke, neurodegeneration (Nelson et al, 2016) and frailty in old age (Guaita et al, 2021) and elevated homocysteine is associated with a reduced blood flow to the small vessels in the brain (reduced microcirculation) (Hassan et al, 2004) which is an important connection because a reduced microcirculation may increase the risk of developing Alzheimers disease, amyotrophic lateral sclerosis (ALS) or Parkinsons disease (Erdener and Dalkara, 2019)
Groups of 50 mice of each sex were administered chlorothalonil at one of two dose levels for 80 weeks, then observed for 11-12 weeks
Many competing services require in-person appointments, IV clinic visits, or complicated onboarding steps that limit scalability
If you've been hesitant about weight-loss injections, or simply want a more convenient route to clinically-backed treatment, this approval changes the landscape dramatically
The Lancet Diabetes & Endocrinology, 12(9), pp
Sensory neuropathy from pyridoxine abuse