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Appetite suppression and lower calorie intake without a robust protein and strength program can lead to disproportionate lean mass loss, which reduces resting metabolic rate, functional strength, and glucose disposal capacity

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Use of GLP-1RAs in an AD mouse model has also shown a neuroprotective role in promoting a reduction in glutamate-induced currents [64]

Additionally, treatment with Liraglutide was associated with reduced mean baseline urinary sodium, extracellular volume, natriuresis, N-terminal pro b-type natriuretic peptide (NT-proBNP) and urinary albumin excretion rate, all of which are indicative of its beneficial effects on renal function [87]

These concerns were often amplified by case reports and early pharmacovigilance signals