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In vitro experiments demonstrated that agrin treatment significantly downregulated PDGFR and claudin-5 expression in a blood-brain barrier co-culture model comprising human brain microvascular endothelial cells and pericytes, suggesting that agrin may induce pericyte death and impair the integrity of the blood-brain barrier

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DOI: 10.1111/j.1440-1789.2010.01160.x

while much more data is needed, its unsurprising that the drugs have become such a hot topic given all their potential applications

Elimination was performed using a high-flux dialyzer (FX60 CorDiax, Fresenius Medical Care) with two HDF sessions of 12 h duration per treatment, interrupted by a 10-h break

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