LMNs are documents written by healthcare providers justifying the necessity of a medication or treatment
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Medical guidelines still recommend metformin first, with Rybelsus for patients needing weight loss or unable to tolerate metformin
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A 2022 report from the California Department of Managed Health Care found that approximately 60% of independent medical reviews for prescription drug denials resulted in overturning the health plan's original decision
Collectively, current evidence supports a model [Figure 1B] in which: (1) a large fraction of early MASH resolution in ESSENCE is likely explained by significant weight loss and associated metabolic reprogramming