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In plants, glutamate and related metabolites act not as classical neurotransmitters, but rather as signalling ligands that modulate calcium flux and redox homeostasis, reflecting a conserved chemical communication logic

When the water-soluble composition of the invention is converted into an aqueous solution for administration, the concentration of the pharmacologically active peptide salt in said solution should preferably be about 0.0000001 to 10 % (w/v), more preferably about 0.000001 to 5% (w/v) or most preferably about 0.00001 to 1% (w/v)

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12 across each anatomical region (AP, area postrema