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Copper itself is an essential cofactor for numerous enzymes involved in collagen synthesis (lysyl oxidase), antioxidant defense (superoxide dismutase) and melanin production (tyrosinase)

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10.1104/pp.010887 Plant Physiol

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IGF-1 and its modified synthetic versions such as Long R3 IGF-1, des(1-3)IGF-1, and R3-IGF-I, have mitogenic effects, which speed up cell replication in laboratory models of different tissues