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We propose staged translation: initial human trials using systemic IV or intranasal delivery, reserving direct CNS approaches for refractory cases

10.1210/jc.2009-0921 87

Atherosclerosis Atherosclerosis it a pathological condition characterized by the buildup of plaque, composed of fats, cholesterol, calcium and other substances, within the intima of large and medium-sized arteries- This process begins with the activation of endothelial cells, setting off a cascade that leads to vessel narrowing, activation of inflammatory pathways, and ultimately, formation of atheromatous plaques [443]

At present, no effective treatment options are available, and little is known about the complex cellular response to TBI during its acute phase

doi: 10.1073/pnas.1414004111 309 YangK.LiuY.ZhangM

Tumor heterogeneity in autophagy-dependent ferroptosis