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PMID 25457918

Website: The GLP-1 Podcast Show Instagram: The GLP-1 Podcast Show LinkedIn: The GLP-1 Podcast Show S1E3 - 29m - Dec 1, 2025 Dr

Unlike natural IGF-1, IGF-1 LR3 has a lower affinity for insulin-like growth factor binding proteins (IGFBPs), which means it can circulate more freely in the bloodstream and reach muscle cells more efficiently

The full timeline for semaglutide to work extends well beyond the first few weeks, with continued weight loss often occurring through the first 12 to 18 months of treatment

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