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Reconstituted peptides may suffer structural damage from ice crystal formation

doi: 10.1016/S0140-6736(08)60694-7 47 GrysiewiczRAThomasKPandeyDK

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The Aib (2aminoisobutyric acid) residue at the Nterminus improves resistance to enzymatic degradation, while modified amino acids such as D2naphthylalanine and Dphenylalanine enhance stability during laboratory handling

Weight Regain After Liraglutide, Semaglutide or Tirzepatide Interruption: A Narrative Review of Randomized Studies