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This study provides preliminary evidence for the cardiovascular benefits of disease-modifying antirheumatic drug therapy in ERA patients and highlights the importance of early treatment in preventing cardiovascular abnormalities [375]

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Oleoylethanolamide (OEA), an ethanolamide fatty acid synthesized in the body, can regulate glucose homeostasis and weight loss by stimulating GLP-1 secretion from intestinal L-cells and insulin secretion from -cells in a GPR119-dependent manner and by affecting the abundance of the bacterium Akkermansia muciniphila [146, 147]

GLP-1 is produced through the proteolytic processing of proglucagon, promoting insulin secretion while inhibiting glucagon production

Patients with obesity have yet another option in their arsenal to fight access weight that is not only very effective but also seems relatively safe, at least in the short and medium term