Novo Nordisks Wegovy (semaglutide), the first and only once-weekly GLP-1 receptor agonist approved for weight management in people with obesity, has been found to help patients lose up to 15 percent of their body weight in over 68 weeks
5.7 Acute Gallbladder Disease Acute events of gallbladder disease such as cholelithiasis or cholecystitis have been reported in GLP-1 receptor agonist trials and postmarketing
Storage: Store in a cool, dry environment
GLP-1 for weight loss Medically reviewed by Dr Crystal Wyllie Last reviewed: 19 Jun 2026 Glucagon-like peptide-1 (GLP-1) agonists are a popular weight loss treatment in the UK
Decisions depend on overall health, medical history, nutritional status, and how stable the patients weight has become
For instance, a 12-month randomized controlled trial involving older adults (ages 60 to 81) demonstrated a 1.1-kilogram increase in fat-free mass with ibutamoren compared to placebo (14)