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As a non-peptide small molecule, it solves the oral delivery challenge through molecular design rather than formulation technology

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M1 macrophage-derived exosomes were transfected with NF-B p50 siRNA and miR-511-3p to foster M1 polarization and subjected to surface modification with the IL4R-targeting IL4RPep-1 peptide (CRKRLDRNC) using a phospholipid anchor

Over time, repeated exposure helps reduce avoidance behaviors and decreases fear responses

The Cochrane Database of Systematic Reviews (4) CD004514