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The short plasma half life of dihexa is a feature, not a limitation: it allows precise temporal control over receptor activation without accumulation toxicity, making it one of the most pharmacologically elegant cognitive enhancers in contemporary neuroscience research

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doi: 10.1016/j.enceco.2025.05.001 9 LiuYKangWLiuSLiJLiuJChenXet al

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Polyamines, such as putrescine, spermidine, and spermine, are critical metabolites derived from arginine via ornithine decarboxylase but not directly from L-citrulline [49]

10.1016/j.cbi.2016.08.019 41 LiF.PattersonA