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Recently, near-infrared spectroscopy (NIRS) was developed as a readily available brain functional imaging technology in daily clinical settings 32,33,34,35,36,37,38

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86 It has been observed in animal models that sustained glucocorticoid stimulation can increase the excitability of glutamatergic neurons and simultaneously decrease the number and plasticity of astrocytes, in addition to decreasing neuronal dendrite connectivity in the hippocampus and frontal cortex, leading to depression

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