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Additionally, cytosolic LPS is directly sensed by inflammatory caspases (e.g., Caspase-4), triggering non-canonical inflammasome responses and pyroptosis, which further amplifies systemic inflammation 144

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The release of proglucagon causes the liver to make glucose (gluconeogenesis converting protein to glucose) as well as to convert fatty acids into ketone bodies

It is often used in hormone replacement therapy (HRT) to treat growth hormone shortages