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Uncontrolled hypertension or cardiac arrhythmias

Mitochondrial dysfunction itself can be categorized into two types: the first type represents a mutation of a gene which is associated with the ATP-generating pathway, while the second one is related to various abnormalities such as genetic, biochemic or metabolic, that may weaken the ability of the mitochondria to produce ATP (Haas et al., 2007)

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If a patient finds the dose escalation to 2.4 mg challenging, it is advisable to delay it for an additional four weeks