Women with underlying conditions such as polycystic ovary syndrome (PCOS) may experience different patterns of menstrual changes, sometimes including cycle normalization as insulin resistance improves
Semaglutide is a single-receptor agonist acting only on GLP-1
That's useful for: Appetite reduction (you feel full sooner and longer) Better post-meal blood sugar control (glucose enters your bloodstream more gradually) But the same mechanism can trigger symptoms, especially when you're sensitive: Nausea and early fullness because your stomach is "holding on" to food longer Bloating and gas because digestion feels delayed and meals may sit heavier Reflux/GERD because a fuller stomach for longer can increase pressure upward Constipation because GLP-1s can also slow intestinal motility (how fast stool moves through) Clinical trials across GLP-1 medications consistently show GI side effects are common
Casta-Abad MT, Montserrat-Capdevila J, Godoy P, et al
For more detail on side effect patterns, our GLP-1 side effects guide can help you understand what many patients notice early on
Ozempic is FDA-approved to treat type 2 diabetes, in conjunction with diet and exercise changes
