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His groundbreaking discoveries have elucidated the importance of Glutathione in neutralizing harmful free radicals and reactive oxygen species, which can contribute to various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions
However, current challenges, such as the lack of tissue-specific targeting of copper-modulating agents and interspecies differences in preclinical models, necessitate further refinement of therapeutic strategies
Another miRNA shown to regulate Nrf2 is miR-34, able not only to target NFE2L2 but also downstream genes involved in cellular response to OS, such as microsomal glutathione S-transferase 1 ( Mgst1 ) and Sirtuin 1 ( Sirt1 ) genes in rat liver during aging [226]
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