JULIE: Okay
The method is characterized by comprising the following steps: in an ultra-high performance liquid chromatograph, respectively mixing a mobile phase A and a mobile phase B according to different proportions to obtain a mobile phase, and carrying out gradient elution on a semaglutide sample, wherein the mobile phase A is selected from a mixed aqueous solution of one or more of trifluoroacetate, perchlorate and hexafluorophosphate, and the pH value is adjusted to be 2-4, and the mobile phase Bis selected from methanol, isopropanol and acetonitrile
Constipation at higher doses Constipation becomes more common as your dose increases, particularly above 1.0 mg
Nighttime urination is common
The small amount of food in your stomach can buffer the initial nausea response that some people experience on an empty stomach
Five hundred and four patients with T2DM were randomized into two arms - a flexible dose of oral semaglutide based on HbA1c and gastrointestinal tolerability (3 mg for 8 weeks, followed by either continuation of 3, 7 or 14 mg) or sitagliptin 100 mg once daily