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When I first learned about SGLT2 inhibitors in pharmacology, what struck me was the elegance of the mechanism instead of forcing the pancreas to produce more insulin or making cells more sensitive, these drugs simply make the kidney excrete the excess sugar

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Next-generation beneficial microbes: the case of Akkermansia muciniphila. Front Microbiol

By contrast, gastrointestinal events such as nausea and vomiting are generally recorded more systematically and are commonly treated as key tolerability endpoints (68)

J Am Soc Hypertens

Include antioxidants like Vitamin C and minerals like selenium in your stack