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Yerushalmi R, Woods R, Ravdin PM, Hayes MM, Gelmon KA

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mentioned that oxidized mtDNA would be cleaved into segments and subsequently transported to the cytoplasm in two steps

The cardiovascular effects of HTY are often attributed to its antioxidant properties, which may reduce oxidative stress through Nrf2-associated responses and changes in downstream detoxification enzymes such as CAT, HO1, NOS, COX2, and GSH, as shown in Fig

(Maciej Kulawik), J.G., Z.G., O.K., M.K

The gut microbiota plays a crucial role in shaping these responses, influencing the TME even in distant organs such as the brain