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Bile AcidDependent Absorption Metabolic constraint during GLP-1RA therapy may arise not only from reduced nutrient inflow but also from altered substrate handling

Based on a comprehensive analysis of the relevant literature, due to the extensive distribution of GLP-1R, its expression has been detected on the surface of related endocrine glands such as the pancreas and digestive glands

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Cannabinoid receptors are widely expressed in islets of Langerhans, and several studies have investigated specific distribution and mechanisms of CB1 versus CB2 receptors in relation to pancreatic endocrine functions 6264

The GCs were bathed in Ringers that contained (in mmol/L) NaCl 145, KCl 5, CaCl 2 2, MgCl 2 1, HEPES 10, and glucose 16