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The most common ones affect the digestive system

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and innate immunity - natural killer cells (NK-cells), neutrophils, natural Treg (nTreg), which interact and are mutually regulated, play a significant role (2225)

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To maintain iron homeostasis, cells employ intricate regulatory mechanisms, including iron uptake via the transferrin receptor (TFR1), storage of iron in ferritin, and ferritinophagy to mitigate the toxic effects of iron overload (Kakhlon and Cabantchik, 2002