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Of these, smoking caused: 35,500 (52%) of all cancer deaths

Specific chemicals, such as the benzaldehyde used in cherry or almond flavorings, can cause respiratory irritation and cough when inhaled, which may not be of significant concern with one use to most users, however it can be deadly to those with the common illnesses of asthma or COPD or other pre-existing conditions, whether inhaled directly or second-hand

Similarly, unweighted UniFrac distance-based PCo revealed a significant separation between smokeless-tobacco- and non-consuming samples across PCo-2 (PERMANOVA, R 2 = 0.03099, p -value = 0.001, Supplementary Figure S2B )

Rujescu, D

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Cigarettes (Smoking and Tobacco Control, Monograph 7)