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Andersson and colleagues (1985) studied acute, nose-only, intermittent exposure to smoke from one, two, or four unfiltered 1R1 reference cigarettes

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Funding YAA was supported by a UKRI Economic and Social Research Council (ESRC) [ES/P000681/1]

Nevertheless, a significant number of biomarker-based studies, cell/ in vitro and animal studies did indicate that e-cigarette exposure can result in oxidative stress, cellular apoptosis, DNA damage, genotoxicity, and tumor growth (Figure 2, and Supplementary file Materials 2 and 3), all of which can potentially increase risk of developing lung cancer or progression of any cancer