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Over time, this can lead to tolerance, where increasingly larger doses are necessary to achieve the medications initial effects, potentially leading to a physical dependence where the body expects the drug for normal function

Use of human induced pluripotent stem cell-derived cardiomyocytes to predict the cardiotoxicity potential of next generation nicotine products

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RESEARCH PAPER Assessment of nicotine dependence symptoms in adolescents: a comparison of five indicators J OLoughlin, J DiFranza, J Tarasuk, G Meshefedjian, E McMillan-Davey, G Paradis, R F Tyndale, P Clarke, J Hanley