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Cotinine is the major metabolite of nicotine and further metabolised mainly to trans-3-hydroxy-cotinine, both quantifiable in body fluids and frequently applied biomarkers for recent tobacco exposure [4]

Tobacco Regulatory Science 2(4):352362

Increased CYP1A1 activity can also increase the degradation of the aryl hydrocarbon receptor , which is an important mechanism for binding polycyclic aromatic hydrocarbons.[ref] CYP1A1 Genotype Report Access this content: An active subscription is required to access this content

The trade organization said that the U.S