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As the PMs gradually lost market share to the NPMs, the PMs began asserting that they were due annual NPM Adjustments, or annual payment reductions, under the terms of the MSA

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This concern is one reason why the US has already been fighting over their use for some years

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We study diverse sources of disease resistance and use modern approaches to develop varieties adapted for North Carolina. Improvements that Benefit Human Health The tobacco industry and consumers have other interests, including color, texture, flavor characteristics and the reduction of harmful constituents such as tobacco-specific nitrosamines (TSNAs), other carcinogenic compounds and potentially nicotine

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